3D electron density map of FVIII bound to PL monolayers.

The 3 density contours are blue at 0.4ς, white at 1.1ς , and red at 1.8ς. The density corresponding to one FVIII molecule is delineated by the yellow dashed box. The height of the unit cell above the monolayer is 10 nm. Panel A shows the top view, looking toward the monolayer along the z-axis. The unit cell dimensions are as for the 2D map: a = 8.1 nm, b = 7.0 nm, and γ = 113°. Panels B and C show side-on views along the y-axis and the x-axis, respectively. The white dashed line denotes the membrane surface (M).