Reduced frequencies of EBV-specific cells in GMCs, as assessed by LDAs.

Frequencies of pCTL (A,C) and pTh (B,D) in PBMCs, Co cells, and GMCs stimulated by autologous (A-B) or allogeneic (C-D) B-EBV cell lines. Three to 10 independent LDA experiments were performed with the EBV-seropositive donors listed in Table 1; pCTL and pTh were not detectable (< 0.01/10⁵ cells) with PBMCs, Co cells, or GMCs from the EBV-seronegative donor no. 8 (not shown). $ indicatesP < .1 as compared with PBMCs; *, P < .05 as compared with PBMCs; †, P < .05 as compared with Co cells.