Monoclonal anti-Ds exhibit variable efficiencies in mediating RBC clearance.

Groups of 3 NOD-scid mice were injected with 10 mg human IgGs and 5 μg of each individual anti-D. RBCs were prepared and injected as in Figure 1. RBC survival was measured as described in “Materials and methods.” The SD at the 4-hour time points were between 0.4% and 13% (mean of 5%) for all the preparations tested.