Effect of RGD peptides on platelet adhesion to SAA.

Platelets were preincubated (15 minutes at 37°C) with peptides GRGDSP (▪) or GRGESP (▧) at the indicated concentrations and then added to BSA-, SAA- or fibronectin-coated wells. The results are expressed as a mean ± 1 SEM for 3 experiments, each designed with triplicates for each peptide concentration. In each experiment, 100% adhesion (control) is the adhesion achieved in the absence of the tested peptide after subtracting adhesion to BSA. *P < .05, **P < .01 when comparing adhesion with and without the tested peptide.