Histology and immunohistochemistry of the lymph node.

Nodular architecture (A), presence of L&H RS cells in the nodules (B,C), internodular proliferation of blasts (D; mitotic figures are indicated with an arrow), predominance of CD20⁺ small B cells (E), presence of CD20⁺ L&H cells (F), Mib-1 positivity of the internodular blasts (G), presence of many CD3⁺ and a smaller number of CD57⁺ T cells surrounding the L&H cells (H,I), and presence of relatively weakly positive CD3 blasts between the nodules and the band of stronger staining CD3⁺ small T cells (J). Original magnifications × 28 (A,E), × 900 (B,C), × 500 (D,F,H.I), × 87 (G), and × 350 (J).