Fig. 1.
Protection of mice from A20 cells after vaccination with the indicated immunogens.
Mice received 2 immunizations, as described in “Materials and methods,” followed by challenge with 5 × 105 viable A20 (A, B) or A20Idneg cells (B). Representative results from 2 to 3 independent experiments are shown. The growth kinetics of A20Idneg in untreated mice is identical to that of wild-type A20. (A) ♦, BiV protein; ▪, BiV cells; ▴, irradiated A20 cells; ■, 26II6 cells + BiV protein; ×, tumor control. (B) ♦, BiVneg cells; ▪, BiV cells + 2.4G2 mAb; ▴, BiVneg cells + BiV protein; ■, BiVIdneg cells; ∗, BiV cells–A20Idneg challenge.
