Fig. 4.
Growth inhibition of established tumors with L19–IL-2 fusion protein.
Volumes (cm3) of F9 teratocarcinoma tumors from syngeneic mice after 6 days of intravenous treatment with 250 000 IU of IL-2 as L19–IL-2 or as an equimolar mixture of IL-2 and L19 or with saline. Each group comprised 6 mice. Therapy was started 6 days after tumor implantation, when tumor size was 0.4 to 0.5 cm3. Arrowheads indicate the days of treatment. Tumor size was determined by caliper measurements in 2 perpendicular dimensions, and tumor volume was determined according to the formula: (short dimension)2 × (long dimension) × 0.52.16 SEs are indicated.
