Comparison of the cerebral chemokine and chemokine receptor mRNA expression in CCR5^−/− and wild-type (wt) mice after intracerebral LCMV infection.

Mice were infected intracerebrally with 10³LD₅₀ LCMV Traub or sham injected intracerebrally with PBS. On the indicated days after infection total RNA was isolated from the brain, and 20 μg total RNA was subjected to RNA protection assay analysis. (A) Cerebral chemokine mRNA expression and (B) cerebral CCR mRNA expression. Quantitative analysis of chemokine (C) and chemokine receptor (D) gene expression based on a similar experiment; columns represent average ± SD of 3 mice.