Time course of primary or peptide-induced footpad swelling in CCR5^−/− and wild-type (wt) mice after LCMV infection.

(A) A primary footpad swelling was elicited by infecting mice with 10³ LD₅₀ LCMV Traub in the right hind footpad; the footpad swelling was measured from postinfection days 6 to 13. (B,C) Mice were infected intravenously with 10³LD₅₀ LCMV Traub and challenged in the right hind footpad with LCMV GP33-41 (50 μg/mL, 30 μL) on day 8 after infection to examine the acute phase (B) or on postinfection day 60 to examine the memory phase (C). Points represent individual mice. “ai” denotes after infection.