Sequences of the C/EBPα duplication and deletion mutants found in the MDS and AML patients.

Panel A represents an alignment of a portion of region 2 of the WT sequence of C/EBPα with the sequence from the MDS patient F3881. Panel B represents an alignment of a portion of region 4 of the WT sequence with the AML patient samples F3820 (24-bp duplication), F3901 (3-bp deletion), J3 (15-bp duplication), and J6 (3-bp duplication). The duplications are in bold text, and the duplicated regions are indicated by underlined italics. The codons for the alanine at position 134 (Ala134) in region 2 and the lysine at position 312 (Lys312) in region 4 are underlined and indicated above and below the nucleotide sequence, respectively.