Fig. 7.
![Fig. 7. Effect of NK cell depletion on IL-18/IL-2 lethality. / (A) Effect of antiasialo-GM1 Ab. SCID mice (n = 5) were pretreated with 1 mg (100 μL) antiasialo-GM1 [asialo] Ab or control normal rabbit serum (NRS) on days 0 and 7 to deplete the NK-cell population. The NK-cell–depleted SCID mice were then treated daily with control PBS or IL-18 (1 μg) plus IL-2 (100 000 IU) once a day for 10 days. (B) Effect of anti-NK1.1 mAb. B6 mice (n = 5) were pretreated with 0.5 mg anti-NK1.1 mAb, CD4 mAb, CD8 mAb, or control antibody on days 0 and 7. Mice were then treated daily with IL-18 (1 μg) plus IL-2 (100 000 IU) once a day for 10 days.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/99/4/10.1182_blood.v99.4.1289/6/h80422124007.jpeg?Expires=1735497687&Signature=q-8wgfNub6k49C1UlgxDqL8rPeEvAjxFlUHjniCKRsYQ2Avf8ava5pflRC9qoXmhMpTUFcoWTmKOOegDIXB82Eeep7mgiUBeQKW~PRr3kJPKjn2ms-GytUk7nzqbMekxcz-8DNTF8Sbuut0T3bxznbywMBjGroy3BIb6XKZroKycYjKts4pKEdtIe5coFjvwkYJXv4IrHIiY8YJI7Cj4NTd0uPFigRcg8fmeGeZFa--TU-RG7Kb7Ke3NCnBqFUnJDqc4jP4hca9lXoj2iV7atGHNr~XwFmwI3ZFW4NXWbdDPtzxCHDo5wjzgv5R8I3OKe83OleqwboVYcy1K5rpSpw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Effect of NK cell depletion on IL-18/IL-2 lethality.
(A) Effect of antiasialo-GM1 Ab. SCID mice (n = 5) were pretreated with 1 mg (100 μL) antiasialo-GM1 [asialo] Ab or control normal rabbit serum (NRS) on days 0 and 7 to deplete the NK-cell population. The NK-cell–depleted SCID mice were then treated daily with control PBS or IL-18 (1 μg) plus IL-2 (100 000 IU) once a day for 10 days. (B) Effect of anti-NK1.1 mAb. B6 mice (n = 5) were pretreated with 0.5 mg anti-NK1.1 mAb, CD4 mAb, CD8 mAb, or control antibody on days 0 and 7. Mice were then treated daily with IL-18 (1 μg) plus IL-2 (100 000 IU) once a day for 10 days.
