Influence of antiretroviral treatment on susceptibility of T cells to TNFR1- and TNFR2-mediated apoptosis.

Freshly isolated PBMCs from HIV⁻ donors (n = 15), HIV-infected patients either nontreated (n = 11) or treated with biRTI (n = 20) or HAART (n = 11) were incubated with coated anti-TNFR1 or anti-TNFR2 mAbs and further analyzed by flow cytometry for apoptosis quantification in CD4 (●) and CD8 T cells (○) as detailed in the legend of Figure 1. Mean values are represented as horizontal bars. Statistical significance was assessed with the Mann-Whitney test.