CIS expression inBCR-ABL–positive and BCR-ABL–negative cell lines.

Real-time RT-PCR amplification of CIS from human hematopoietic cell lines, shown as ratios of CIS/GAPDHexpression. For STI571-exposed cells, results are expressed in comparison to cells not exposed to the compound. (A) Time-course ofCIS expression in KYO1 cells exposed to 1 μM STI571. (B) Baseline expression of CIS in human hematopoietic cell lines. (C) CIS expression after exposure to 1 μM STI571 for 10 to 24 hours.