Fig. 1.
Morphology of red blood cells from wild-type and mutant mice.
Red blood cell preparations from wild-type,apoE−/−, SR-BI−/−, SR-BI−/−/apoE−/−, andhbd mice were examined by means of standard blood-smear Wright-Giemsa light microscopy photographed at × 100 magnification (panels A-E); DIC microscopy photographed at × 100 magnification (panels F-J) (arrow shows inclusions [panels H, I] and hemoglobin in target cell [panel J]; transmission electron microscopy (panels K-P) (panel P is a higher-magnification image of anSR-BI−/−/apoE−/−erythrocyte that shows mitochondria and ribosomes within the membrane-enclosed inclusion (arrows).