Influence of TM-β1 on human cell engraftment in NOD/SCID mice.

Percentages (A) and absolute numbers (B) of human CD45⁺cells within murine organs—bone marrow (BM), spleen (SPL), mesenteric lymph nodes (MLN), peripheral blood (PB), and thymus (THY)—of NOD/SCID mice injected with CD3-depleted human UCB 12 to 15 weeks earlier. Mouse conditioning consisted of radiotherapy alone (░) or radiotherapy and injection with TM-β1 (▪). Each bar represents the mean ± SD of 28 mice (RT) or 39 mice (RT + TM-β1), respectively. Calculation of absolute numbers of cells was performed as described before.26 Differences in engraftment between 2 groups were significant for all organs (P < .0005 for bone marrow, spleen, mesenteric lymph nodes, and peripheral blood,P = .002 for thymus).