Effect of AT, DEGR-F.Xa, or Trp⁴⁹-modified AT on changes in MAP in rats administered ET.

Changes in MAP after the administration of ET (5 mg/kg) were determined. (A) AT (250 U/kg, open circles), DEGR-F.Xa (3 mg/kg, open squares), Trp⁴⁹-modified AT (250 U/kg, open triangles), or saline (closed circles) was administered intravenously 30 minutes before ET administration. (B) AT (250 U/kg, open circles) or saline (closed circles) was intravenously administered 30 minutes after ET administration. Pre indicates the time just before ET administration. Data are expressed as means ± SD of 5 animals. *P < .01 versus ET plus saline.