Effect of AT, DEGR-F.Xa, Trp⁴⁹-modified AT, AT pretreated with indomethacin (IM), or iloprost on increases in lung levels of TNF-α 90 minutes after ET administration in rats.

Lung levels of TNF-α were determined 90 minutes after ET administration. Concentration of AT, DEGR-F.Xa, Trp⁴⁹-modified AT, IM, or iloprost was as in Figures 2A and12. Control animals were administered saline alone. Data are expressed as means ± SD of 4 animals. *P < .01 versus control. †P < .01 versus ET plus saline. ††P < .05 versus ET plus saline.