A G376A polymorphism was identified in the Leu33 encoding β3 integrin allele from Donor A.

The complete ORFs of both αIIb and β3 integrins were sequenced from cDNA obtained from the platelets of Donor A. Sequencing identified a single, novel polymorphism in the β3 cDNA with adenine or guanine at position 376, for which Donor A is heterozygous. This SNP, indicated by the arrow, results in the replacement of arginine with glutamine at position 93 in the β3Leu33 allele.