Fig. 3.
Dose titration of individual tumor lines.
Various doses of tumor cells were subcutaneously injected into naive recipients: 5 × 106 (5 mice/group), 1 × 106 (8 mice/group), 1 × 105 (10 mice/group), 1 × 104 (10 mice/group), and 1 × 103 (10 mice/group). Percentages of mice that developed and progressed with tumor are indicated for each challenge dose. ■ = C1498, □ = C1498/B7-1, and ● = C1498/B7-2. All mice that progressed with tumor died or were electively killed because of tumor size larger than 250 mm2. Combined results of 3 independent experiments are shown.
