DNA sequence of CD109 exon 19 and flanking introns.

The CD109 nucleotide 2108 A>C SNP was found to lie 3 nucleotides from the 5′ end of CD109 exon 19. The DNA sequence of exon 19 and of flanking introns 18 and 19 is shown (GenBank accession no. AF410460). Exon 19 sequence and the corresponding predicted peptide sequence are shown in bold. Nucleotides are numbered sequentially, beginning at the 5′ end of intron 18. Amino acid coordinates (parentheses) correspond to the CD109 numbering scheme of Lin et al.10 Both allele-specific codon 703 variants (Gov^a, TAC;Gov^b, TCC) are shown (box). The nucleotide 2108 A>C SNP results in a Tyr to Ser amino acid substitution at position 703 of CD109.