Fig. 5.
Fig. 5. Lack of MHC restriction in chRec-mediated tumor cell killing by transduced CTLs. / 51Cr-labeled GD2+ LAN-5 neuroblastoma cells and autologous EBV-LCLs were preincubated for 30 minutes with monoclonal antibodies recognizing monomorphic determinants of HLA class I or HLA class II, then coincubated for 4 hours with 14.G2a-ζ–transduced CTL at a 20:1 effector-to-target ratio.

Lack of MHC restriction in chRec-mediated tumor cell killing by transduced CTLs.

51Cr-labeled GD2+ LAN-5 neuroblastoma cells and autologous EBV-LCLs were preincubated for 30 minutes with monoclonal antibodies recognizing monomorphic determinants of HLA class I or HLA class II, then coincubated for 4 hours with 14.G2a-ζ–transduced CTL at a 20:1 effector-to-target ratio.

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