Fig. 5.
Lysis of neuroblastoma cells expressing native ALK.
Anti-p280-89 (A) and p375-86 (B) CTL lines recognize and kill in an HLA-restricted way neuroblastoma cells. IMR-32 (HLA-A2.1+/ALK+), SK-N-SH (HLA-A2.1−/ALK+), and NB-5 (HLA-A2.1+/ALK−) cell lines were used as targets in a standard 51Cr release assay. E/T ratio: 50:1 (▪), 25:1 (■), 12:1(▤). Results of 1 representative experiment of at least 3 performed are shown.
