Fig. 1.
Fig. 1. Anemia induction and lethality in gene-targeted mice. / (A) Schematic of anemia induction regime. (B) Hematocrits of 10- to 12-week-old, weight-matched female mice having undergone the aforementioned treatment. Results (average ± SEM) are based on 5 separate experiments using at least 5 mice per genotype per experiment. Compared with same-day WT hematocrit, * and ** denoteP < .05 and < .005, respectively. # representsP < .05 forIL-3−/−;EpoR+/− orGM-CSF−/−;EpoR+/−, when compared with EpoR+/− hematocrit; % and @ represent P < .05 when comparing WT mice with mice lacking GM-CSF or IL-3, respectively. (C) Survival rates after PHZ injection. Results are based on the cumulative studies of at least 30 mice per genotype.

Anemia induction and lethality in gene-targeted mice.

(A) Schematic of anemia induction regime. (B) Hematocrits of 10- to 12-week-old, weight-matched female mice having undergone the aforementioned treatment. Results (average ± SEM) are based on 5 separate experiments using at least 5 mice per genotype per experiment. Compared with same-day WT hematocrit, * and ** denoteP < .05 and < .005, respectively. # representsP < .05 forIL-3−/−;EpoR+/− orGM-CSF−/−;EpoR+/−, when compared with EpoR+/− hematocrit; % and @ represent P < .05 when comparing WT mice with mice lacking GM-CSF or IL-3, respectively. (C) Survival rates after PHZ injection. Results are based on the cumulative studies of at least 30 mice per genotype.

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