![Fig. 4. Influence of receptor antagonists and selective serotonin reuptake inhibitors on 5-HT actions against group 1 BL cells. / (A) L3055 cells were pretreated for 30 minutes with the 5-HT receptor antagonists (SDZ205-557 [10 μM], granisetron [1 μM], methysergide [1 μM]), alone or in combination, before the addition of 125 μM 5-HT (+ 5-HT) or control medium (control), and DNA synthesis was assessed as in Figure 1A. (B) As for panel A, but cells were cultured with 150 μM 5-HT alone (0; striped bar) or with 5-HT after 30-minute pretreatment with the SSRI, fluoxetine (black bars), citalopram (white bars), or paroxetine (gray bars) at concentrations indicated. Results are expressed as % control (no addition) values. Data are represented as the mean ± SEM of 3 (A) or 4 (B) separate experiments.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/99/7/10.1182_blood.v99.7.2545/6/h80722355004.jpeg?Expires=1735512196&Signature=SwqTuSAUAxoGSE1lERMwA5BzIxTRz35WfYMxZi6p6~ZVNxBFtOaJpj7DaispSqs5fYNDTuDOj5R11NIEu0f4en8eZZkvcE5BsmUo~EOT3UzhFKMnYhjs48jyh0kngNte8d-DlqTbHJmz7XL5vlqayqBkO~61aldJwC00xyc8plXFNKxdXpgaZGuIfP86G5HB5Xt6mVmJvvEnqBO8N~l6KPp3J8nmuy6Bp~sST0zfXkQ-LAgd30IYiVN4HtBtPmTKpBbZ0ijmZRgqEMW9SUyolrbZNgBlTRWAArtTCnsyxTjuAFyoHgTAzUKijVzt86QmYYEXfSC88rKnh8Vn-xhN3A__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Influence of receptor antagonists and selective serotonin reuptake inhibitors on 5-HT actions against group 1 BL cells.
(A) L3055 cells were pretreated for 30 minutes with the 5-HT receptor antagonists (SDZ205-557 [10 μM], granisetron [1 μM], methysergide [1 μM]), alone or in combination, before the addition of 125 μM 5-HT (+ 5-HT) or control medium (control), and DNA synthesis was assessed as in Figure 1A. (B) As for panel A, but cells were cultured with 150 μM 5-HT alone (0; striped bar) or with 5-HT after 30-minute pretreatment with the SSRI, fluoxetine (black bars), citalopram (white bars), or paroxetine (gray bars) at concentrations indicated. Results are expressed as % control (no addition) values. Data are represented as the mean ± SEM of 3 (A) or 4 (B) separate experiments.
