Responses of Lyn-deficient and wild-type platelets to agonists of other G-protein–coupled receptors.

Lyn-deficient and wild-type murine platelets were activated with U46619or ADP at low and high concentrations. Lyn-deficient platelets aggregated normally in response to low and high concentrations ofU46619 and ADP; therefore, Lyn kinase function is not required for all GPCR signaling. Results are representative of 5 separate experiments.