Model of hemoglobin production during erythroid differentiation in adults.

Patterns for the accumulation of mean HbF (solid line) and HbA (dashed line) are shown with corresponding scales on the left and right y-axes, respectively, and cell types on the x-axis. The vertical dotted line identifies the transition from a rising to falling rate of proliferation. Bars at the top of figure denote the apparent fluorescence-based distribution of hemoglobin within the populations (see text for details). Hemoglobin levels attributed to the mature erythrocytes were obtained from HPLC analyses using peripheral blood from normal, healthy donors.