Genotype of newborn pups and plasma levels of AT antigens and activities.

(A) Genotype of newborn mice from the pairing of AT+/− andAT+/+ mice. One hundred forty-one pups were born from 20 pairings, and the genotypes were determined by PCR analysis. Plasma levels of AT antigens (B) and activities (C) are measured as described in “Materials and methods.” AT antigens and activities were significantly reduced in AT+/− mice compared withAT+/+ mice (n = 8; P < .01). Values are means ± SD.