Fig. 3.
Activation of platelets with calcium ionophore A23187 (and 2.5 mM CaCl2) mimics the effect of thrombin on adducin phosphorylation and proteolysis.
Direct activation of PKC by influx of calcium ions caused PKC phosphorylation of adducin (B) as well as proteolysis (C). At low concentrations of ionophore, phosphorylation occurred without proteolysis (lane 2).
