DKO mice have reduced parasitemia in P yoelii infection.

Each graph represents one experiment. DKO or WT mice (6-10 per group) were infected intraperitoneally with 10⁶ parasitized RBCs at day 0 (P yoelii or P chabaudi). Parasitemia was determined at specified days after infection by counting the number of parasitized RBCs in a total of at least 300 RBCs on Wright-Giemsa–stained thin blood smears. Data are represented as the mean ± SD. Significantly different groups (P < .05) are marked by an asterisk. (A, B) Mice infected with P yoelii. Parasitemia in WT mice was significantly greater than that of DKO mice at days 5 to 14 after infection. (C) Mice infected withP chabaudi. There was no difference between the strains in parasitemia.