Histology of 4 regions of the brain from BM-transplanted GS mice.

Hematoxylin and eosin staining of the choroid plexus (CP), the lateral geniculate nucleus (LGN), the amygdala (AMG), and the deep cerebellar nucleus (CbN) isolated from BMT-PPCA–treated GS mouse at 9 months after transplantation showed clear reduction of storage in neural cells compared to an age-matched GS animal. The overall brain architecture was clearly improved due to the clearance of storage material in endothelial cells and perivascular and leptomeningeal macrophages. Storage in some of the neurons in the amygdala and cerebellar nucleus was also cleared. Size bar corresponds to 30 μm.