Specific lysis of DBY-transduced female EBV target cells by the HLA-DQ5 HY CTL.

Target cells were added to the HLA-DQ5 HY CTL at indicated effector-target ratios, and ⁵¹Cr release was measured after 4 hours. (A) Lysis of male EBV and DBY-transduced female EBV cells by the HLA-DQ5 HY CTL. (B) Lysis of male EBV cells could be blocked by a 10-fold excess of unlabeled DBY-transduced female EBV cells, whereas unlabeled EBV cells transduced with the control vector containing the GFP did not affect the CTL-induced lysis of male EBV cells.