CLL cell CCR7 expression and function in relation to lymph node enlargement.

(A) The bar represents the average mean fluorescent intensity (MFI) for each group. Receptor expression was measured by FACS analysis, using an indirect immunofluorescence technique. (B) This panel shows inhibition of CLL cell TEM migration by 2 concentrations (50 and 100 μg/mL) of blocking anti-CCR7 mAb. The numbers on the X-axis refer to the patients listed in Table 1. The error bars represent SEMs of triplicate measurements. Control rat IgG2a antibody had no inhibitory effect.