Fig. 4.
Free-etoposide clearance, according to age and cycle number.
(A) Free-etoposide clearance measured in 23 patients during several cycles decreased with age (r = −0.45;P2 = .034), suggesting that the lower dose rate in older patients may have been due to decreased drug clearance. (B) Free-etoposide clearance increased with cycle number (paired comparison of cycles 1 and 6 in 12 patients;P2 = .015 after applying a Bonferroni adjustment for multiple comparisons), indicating that at fixed dose rates, serum levels of free etoposide would fall cycle after cycle. The number of patient samples is shown above the y-axis.
