Freeze-frame photomicrographs demonstrate that the APC are avidly phagocytic and ingest the apoptotic CTCL cells.

(A) CTCL cells (arrows) begin to adhere to the cell membrane of an APC, at 8 minutes after the addition of CD3 antibody. (B) The CTCL cells (arrows) become surrounded by a pseudopodial extension of the APC membrane, at 9 minutes. (C) The CTCL cells (arrows) have become fully internalized in the cytoplasm of the APC, at 10 minutes. Original magnification × 400.