Fig. 2.
Morphologic changes in APL cells in BM after As4S4treatment.
(A) Promyelocytes from a patient with APL (patient 8) had dense azurophilic cytoplasmic granules and ectoplasm with Wright stain before treatment. The nuclei had fine chromatin strands and nucleoli. (B) After 18 days of As4S4treatment, cells from the same patient had degranulated cytoplasm. The nuclei had an irregular contour and coarse chromatin strands. (C) Other degenerating cells in the same smear as that in Figure 2B. Original magnification, × 1000.
