Fig. 7.
Dynamic changes in peripheral WBC counts during As4S4 treatment in 9 patients with newly diagnosed APL.
Four patients had baseline WBC counts above 10 × 109/L, and 5 had such counts during As4S4 treatment. The peak values in WBC counts ranged from 15.1 to 45.9 × 109/L on the 4th to 22nd day after administration of As4S4. In 4 patients, the WBC counts decreased after a few doses of hydroxyurea. Patient 7 received a low dosage of harringtonine (2 mg/day) for 3 days. In 4 other patients (dotted lines), the high WBC counts resolved spontaneously, without administration of cytotoxic drugs.
