Fig. 9.
Blood arsenic concentration in patients with APL treated with As4S4.
During the 2-weeks-on and 2-weeks-off treatment schedule, blood arsenic levels increased during the 2 weeks of continued administration of oral As4S4 and gradually returned to normal levels after discontinuation. Blood samples were obtained for arsenic analysis every week. Blood arsenic concentrations are shown in micrograms per liter on the y-axis; the x-axis shows the days of As4S4 administration. The −7 and −14 indicate discontinuation of treatment with As4S4 for 7 and 14 days, respectively.
