The distribution of secondary chromosomal abnormalities in 965 patients with APL characterized by the t(15;17) reveals a nonrandom pattern with frequent gain of chromosome 8.

Complete chromosomal gain or structural rearrangements leading to partial chromosome gain is depicted by green bars on the right of each chromosome, and complete chromosomal loss or structural rearrangements leading to partial chromosome loss is depicted by red bars on the left. The numbers above the bars indicate the number of patients with the abnormality. Black arrowheads indicate the breakpoints of structural rearrangements; the numbers on the right of each arrowhead indicate the number of patients with a structural abnormality involving this breakpoint.