Fig. 2.
![Fig. 2. Ability of TGF-β to inhibit T-cell proliferation is significantly greater in nontransduced CTLs when compared with HATGF-βRII-Δcyt–transduced CTLs. / Nontransduced CTLs, eGFP-transduced CTLs, and HATGF-βRII-Δcyt–transduced CTLs were stimulated with irradiated autologous LCLs and IL-2 ± 5 ng/mL TGF-β1. Proliferative responses were measured after 72 hours of incubation by measurement of3[H] thymidine uptake. The mean percentage of inhibition by TGF-β was measured in nontransduced CTLs (black), eGFP-transduced CTLs (white), and HATGF-βRII-Δcyt–transduced CTLs (gray). The graph represents a pooled analysis of the mean inhibition of TGF-β on3[H] thymidine uptake in the 8 CTL lines tested.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/99/9/10.1182_blood.v99.9.3179/6/h80922475002.jpeg?Expires=1735561320&Signature=PqhT7HP545ZvN-ol84VZdqVGLN5WePXfARsz~lLKep1741HZpb-k6F-VF1yA4jwO2yvu3QdR-zwLotRFPFiMOKnRwwexyoimseLfK3uZdkrip80uBrHzMN1yFt9aLnrxAWoFT1W0JZe6V91MbVH~TGLK-5-qYfejkNR-qJtEldDOaeiHijpkjaCT0tbp0Ko2co1zx~tSjH8tFpOGBbyaAmauosbDLyuv7dDkYkBablgIxcbaxAltY7gj2zi2bYaLfEQAF8Dtjb-7dzlmAg2fqbSC7YlTCUawj~2LRMKaJM9aJh7m7KrwP-jjK0r4h9HCwE~tf7pWkSo6Ikd1msICeA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Ability of TGF-β to inhibit T-cell proliferation is significantly greater in nontransduced CTLs when compared with HATGF-βRII-Δcyt–transduced CTLs.
Nontransduced CTLs, eGFP-transduced CTLs, and HATGF-βRII-Δcyt–transduced CTLs were stimulated with irradiated autologous LCLs and IL-2 ± 5 ng/mL TGF-β1. Proliferative responses were measured after 72 hours of incubation by measurement of3[H] thymidine uptake. The mean percentage of inhibition by TGF-β was measured in nontransduced CTLs (black), eGFP-transduced CTLs (white), and HATGF-βRII-Δcyt–transduced CTLs (gray). The graph represents a pooled analysis of the mean inhibition of TGF-β on3[H] thymidine uptake in the 8 CTL lines tested.
