Alignment of the different hIAN proteins found by screening the Genbank database with the hIAN1 GTP/GDP–binding domain.

Protein-sequence alignment was performed by means of ClustalX and displayed with Mac Box Shade 2.15 programs. Conserved amino acids are shaded in black while similar amino acids are shaded in gray. G1, G2, G3, and G4 motifs of the different hIAN proteins are heavily underlined; the coiled-coil domains of hIAN1 and hIAN7 are underlined; and the hydrophobic motif of the hIAN5 protein is boxed.