Fig. 5.
Fig. 5. Naive CD4+ T cells are present in a thymoma with ps MG. / Confocal laser scanning microscopy analysis of the thymomas of a patient with ps-MG and of a representative patient with development of MG before thymoma detection showing abundant naive CD4+ T cells in both tumors. By contrast, naive CD4+ T cells were almost undetectable in 2 MG(−) thymomas. Moreover, naive CD8+ T cells were virtually absent in one MG(−) thymoma (patient 10). Sections were double stained with either CD4-Cy3 (red) and CD45RA-Cy2 (green) or CD8-Cy3 (red) and CD45RA-Cy2 (green). Cells with double staining show a yellow fluorescence in electronic overlays of the red and green images. Percentages of naive T-cell subsets as determined by flow cytometry (Table 2) are given at the bottom of each panel for comparison. Images are representative of at least 20 microscopic high-power fields studied per double staining in each patient. Original magnification, × 400.

Naive CD4+ T cells are present in a thymoma with ps MG.

Confocal laser scanning microscopy analysis of the thymomas of a patient with ps-MG and of a representative patient with development of MG before thymoma detection showing abundant naive CD4+ T cells in both tumors. By contrast, naive CD4+ T cells were almost undetectable in 2 MG(−) thymomas. Moreover, naive CD8+ T cells were virtually absent in one MG(−) thymoma (patient 10). Sections were double stained with either CD4-Cy3 (red) and CD45RA-Cy2 (green) or CD8-Cy3 (red) and CD45RA-Cy2 (green). Cells with double staining show a yellow fluorescence in electronic overlays of the red and green images. Percentages of naive T-cell subsets as determined by flow cytometry (Table 2) are given at the bottom of each panel for comparison. Images are representative of at least 20 microscopic high-power fields studied per double staining in each patient. Original magnification, × 400.

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