Proliferation of autologous and allogeneic T cells in response to CD40-activated CLL cells.

(A) Proliferation of CD4⁺ autologous and allogeneic T cells in response to CD40-activated CLL cells after 1 (day 8), 2 (day 15), and 3 (day 22) stimulations with CD40-activated CLL cells. Mean and SD are shown. Control T cells that were not stimulated did not survive in culture for this period. (B) Proliferation of CD8⁺ autologous and allogeneic T cells in response to CD40-activated CLL cells after 1 (day 8), 2 (day 15), and 3 (day 22) stimulations with CD40-activated CLL cells. Mean and SD are shown. Control T cells that were not stimulated did not survive in culture for this period. In each case data represent the mean of at least 3 separate donor cells tested.