Specific proliferation of autologous T cells in response to unstimulated CLL cells.

(A) Specific proliferation of autologous T cells in response to unstimulated CLL cells after stimulation with CD40-activated CLL cells is shown for patient CLL 11 and is representative of results seen in 5 of 7 experiments performed. (B) Proliferative response of autologous T cells is inhibited by addition of antibodies against MHC class I (W6/32) and MHC class II molecules (CR3/43). Results are shown for patient CLL 6 and are representative of 3 similar experiments performed. Thymidine incorporation was determined in cpm ± SD of triplicate determinations.