Fig. 3.
SU11652, SU11654, SU11655 inhibit the growth of mast cell lines expressing mutant Kit.
Cells (5 × 105) (C2, BR, or P815) were cultured in complete medium with no drug or with SU11652, SU11654, or SU11655 at the indicated concentrations. Cells were collected after 24, 48, or 72 hours of culture and were counted to determine the number of remaining cells in each well. No inhibition of cell growth was noted at concentrations lower than 0.01 μM (C2 and BR) or lower than 0.25 μM (P815) (data not shown). Data are presented as percentage of control (untreated) cells. One of 4 representative experiments is shown.
