Fig. 5.
SU11652, SU11654, and SU11655 induce PARP cleavage in cell lines expressing mutant Kit.
Cells (10 × 106) were cultured in complete medium with no drug or with SU11652, SU11654, or SU11655 at the indicated concentrations for 24, 48, or 72 hours. The cells were then collected and lysed, and protein was quantitated. Approximately 40 μg protein/condition was run on a 10% SDS-PAGE gel, and Western blot analysis was performed for PARP.
