Dependence of adhesion of rGPIa/IIa-Ibα-liposomes with different exofacial densities of rGPIa/IIa and rGPIbα on shear rate, in the presence and absence of VWF.
Images were obtained after 3 minutes of perfusion on the collagen surface at different shear rates, as indicated, in the presence and absence of 10 μg/mL soluble VWF. (A) The rGPIa/IIa-Ibα-liposomes with exofacial densities of rGPIa/IIa and rGPIbα at 2.17 × 103 and 1.00 × 104 molecules per particle, respectively. (B) The rGPIa/IIa-Ibα-liposomes with exofacial densities of rGPIa/IIa and rGPIbα at 2.19 × 103 and 5.27 × 103 molecules per particle, respectively. (C) The rGPIa/IIa-Ibα-liposomes with exofacial densities of rGPIa/IIa and rGPIbα at 0.96 × 103 and 1.08 × 104 molecules per particle, respectively.
