Fig. 6.
Fig. 6. Inhibitory effect of GUR83-35 or Gi9 on the adhesion of rGPIa/IIa-Ibα-liposomes to the collagen surface under flow conditions. / Relative surface coverage of rGPIa/IIa-Ibα-liposomes with different exofacial densities of rGPIa/IIa and rGPIbα, in the presence of specific antibody and 10 μg/mL soluble VWF, are shown. Values are the mean ± SD; n = 6. White bar indicates control mouse; black bar, GUR83-35 (+); grey bar, Gi9(+). (A) The rGPIa/IIa-Ibα-liposomes with exofacial densities of rGPIa/IIa and rGPIbα at 2.17 × 103 and 1.00 × 104molecules per particle, respectively. (B) The rGPIa/IIa-Ibα-liposomes with exofacial densities of rGPIa/IIa and rGPIbα at 2.19 × 103 and 5.27 × 103 molecules per particle, respectively. (C) The rGPIa/IIa-liposomes with an exofacial density of rGPIa/IIa at 2.22 × 103 molecules per particle.

Inhibitory effect of GUR83-35 or Gi9 on the adhesion of rGPIa/IIa-Ibα-liposomes to the collagen surface under flow conditions.

Relative surface coverage of rGPIa/IIa-Ibα-liposomes with different exofacial densities of rGPIa/IIa and rGPIbα, in the presence of specific antibody and 10 μg/mL soluble VWF, are shown. Values are the mean ± SD; n = 6. White bar indicates control mouse; black bar, GUR83-35 (+); grey bar, Gi9(+). (A) The rGPIa/IIa-Ibα-liposomes with exofacial densities of rGPIa/IIa and rGPIbα at 2.17 × 103 and 1.00 × 104molecules per particle, respectively. (B) The rGPIa/IIa-Ibα-liposomes with exofacial densities of rGPIa/IIa and rGPIbα at 2.19 × 103 and 5.27 × 103 molecules per particle, respectively. (C) The rGPIa/IIa-liposomes with an exofacial density of rGPIa/IIa at 2.22 × 103 molecules per particle.

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