Formation of melphalan-induced DNA ICLs in plasma cells isolated from melphalan-naive and melphalan-treated MM patients.

ICL formation, as represented as percentage decrease in tail moment, increased with dose of melphalan to the same extent in both melphalan-naive (A) and melphalan-treated patient populations (B). No significant differences in ICL formation in melphalan-naive (–▪–) and melphalan-treated (--●--) patients were observed when expressed as mean percentage decrease in tail moment ± SE (C).