The G-CSF–induced mobilization of progenitor cells is enhanced by pretreatment with anti–LFA-1 antibodies.

Mice were pretreated with a single injection of 100 μg neutralizing anti–LFA-1 (H154.163, n = 11) or non-neutralizing anti–LFA-1 (H155.78, n = 6), or anti–ICAM-1 (YN1/1.7, n = 3) or saline (n = 16). Twenty-four hours later, 5 μg G-CSF was started by daily intraperitoneal injections for 3 days. Twenty-four hours after the last injection, mice were killed and blood was harvested. Results are expressed as mean ± SD. *P <. 05 as compared with the saline-pretreated controls.