Comparison of TAT complex formation and platelet activation.

Clot time was calculated to be 4.7 ± 0.2 minutes for the group studied. Data are shown as the mean ± SEM. The TAT (♦) composite represents 35 experiments and has an initiation phase duration up to 4.6 ± 0.6 minutes with an increasing rate of propagation of 83.9 ± 3.8 nM/min. The detected maximum level reached was 851 ± 53 nM TAT. Osteonectin (○) released from activated α-granules of platelets (from 18 experiments) showed an initial baseline in whole blood of 6.9 ± 1.2 nM. The propagation phase began at 1.9 ± 0.2 minutes and increased to 44.6 ± 6.7 nM at a rate of 6.8 ± 0.4 nM/min.